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KMID : 1036920120170010039
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Annals of Pediatric Endocrinology & Metabolism
2012 Volume.17 No. 1 p.39 ~ p.44
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Serum Alkaline Phosphatase Levels in 10-20 Year Old Healthy Korean Children and Adolescents - Based on the 2009 Korean National Health and Nutrition Examination Survey -
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Seo Ji-Young
Chae Jeong-Don
Park Hong-Kyu
Kim Dong-Ho
Lee Jun-Ah
Lim Jung-Sub
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Abstract
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Purpose: Serum alkaline phosphatase (sALP) levels show great variation with age and sex in children and adolescents. We aimed to study pediatric age- and sex-specific reference ranges for sALP and how the pattern changed according to age .
Methods: Cross-sectional results from 1366 healthy Korean children and adolescents (10-19.9 years) from the Korean National Health and Nutrition Examination Survey were analyzed. We constructed age- and sex-specific reference data for sALP with a Hitachi Automatic Analyzer 7600 using Pureauto S ALP. We assessed its peak both in relation to age.
Results: Reference values for sALP according to age were constructed. Peak sALP levels were found at 12-13 years in boys (P < 0.001). Total sALP levels decreased to the adult level at the age of 17 in boys and 15 in girls, respectively.
Conclusion: This study provides reference values for sALP by age for Korean children and adolescents. This normative data that includes upper and lower limits will provide a basis from which to better evaluate sALP levels, especially for bone disorders such as rickets and vitamin D deficiency. However, caution should be made in interpreting sALP levels because different buffers might lead to different values in the same serum.
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KEYWORD
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Alkaline phosphatase, Reference values, Korean, Child, Adolescent, Sex characteristics
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